GENERIC NAME: Simvastatin

COMMON BRANDS: Zocor, Flolipid, Simcard

Simvastatin comes under the drug class known as HMG-CoA reductase inhibitors, also known as statins. A class of drugs is a group of medications that act in a similar way. These drugs are often used to treat the same conditions. Simvastatin is a prescription drug. It is available in two forms, a tablet, and a suspension form, and both forms are taken orally.

Statins work by reducing the body’s cholesterol production. They also decrease the amount of cholesterol and triglycerides running through the body. Simvastatin oral tablet is available as Zocor (brand-name). It is also available in pharmacies as a generic drug. In some cases, they may not be available in all strength or form as the brand-name drug.

What are the uses of Simvastatin?

Simvastatin is used along with proper nutrition to lower “bad cholesterol” and fats (for example LDL, triglycerides) and increase “good cholesterol” (HDL). It acts by decreasing the amount of cholesterol produced by the liver. The chances of heart disease, strokes and heart attacks can be reduced by Lowering “bad cholesterol” and triglycerides and raising “good cholesterol”.

In addition to having proper nutrition (for example a low-cholesterol/low-fat diet), other lifestyle modifications can help this medication work better include regular exercise, losing weight if overweight, and quitting smoking. Consult your doctor/physician for more details.

How to use Simvastatin?

This medication must be taken orally as directed by your doctor/physician, usually once a day in the evening. If you are using the tablet form, you may take this medication with or without meals.

If you are using the liquid form, take this medication on an empty stomach. Shake the bottle well before each dose. Carefully measure the dose quantity using a special measuring cup/spoon. Do not use a household spoon, and it may not measure the correct dose.

Dosage depends on your medical condition, age, response to treatment, and other medications you may be taking. Tell your doctor/physician and pharmacist about all the products you use (for example prescription drugs, nonprescription drugs, and herbal product). Chinese patients taking niacin may need lower doses of simvastatin. Ask your doctor for further details.

The typical maximum dose for this medication is 40 mg per day. If you are informed by your doctor/physician to take more than 40 mg, continue on that same dose. Nonetheless, promptly talk to your doctor/physician about the dangers and benefits of the higher doses.

Do not raise your dose or take this medication more frequently than prescribed dose. Your condition will not improve any sooner, and the chance of severe side effects can increase.

Eating/drinking grapefruit juice while using this medication must be avoided unless your doctor/physician advised. Grapefruit can increase the concentration of this medication in your bloodstream. Consult your doctor/physician/pharmacist for further details.

Take this medication regularly to improve your condition. Do not forget to take it at the same time each day. It is essential to continue taking this medication even if you feel great. Most of the people with high cholesterol or triglycerides do not feel ill.

It is crucial to continue to follow your doctor’s instructions about nutrition and exercise. You may take up to 4 weeks to notice the full benefit of this drug.

What are the side effects of Simvastatin?

Remember that your doctor/physician has prescribed this medication because he or she has found that the benefits are higher than the risk of side effects. Most of the people using this medication do not experience serious side effects.

A minimal number of people taking simvastatin may experience little memory problems or confusion. If these rare outcomes occur, talk to your doctor.

Rarely, statins may induce or worsen diabetes. Talk to your doctor/physician about the benefits and risks.

This drug may rarely produce muscle problems (which can sometimes lead to severe conditions known as rhabdomyolysis and autoimmune myopathy). Inform your doctor/physician immediately if you observe any of these below symptoms during treatment, and if these symptoms continue after your doctor/physician advice you to stop this drug: muscle pain/weakness/tenderness (especially with fever or unusual tiredness), signs of kidney problems (such as change in the amount of urine).

This medication may rarely cause liver problems. If you see any of the following rare but serious side effects, tell your doctor/physician immediately: yellowing eyes/skin, dark urine, severe stomach/abdominal pain, persistent nausea/vomiting.

A severe allergic reaction to this drug is uncommon. However, seek immediate medical assistance if you notice any symptoms of a severe allergic reaction such as rash, itching/swelling (especially of the face/tongue/throat), trouble breathing, severe dizziness.

This is not a list of all possible side effects. If you mark other effects not listed above, contact your doctor or pharmacist.

What are the precautions while using Simvastatin?

Before taking simvastatin, inform your doctor/physician/pharmacist if you are allergic to it, or if you have any other allergies. This product may include some inactive ingredients, which can produce allergic reactions or other problems. Talk to your pharmacist for further details.

Before taking this medication, inform your doctor/physician/pharmacist about your medical history, especially if you have liver disease, kidney disease or alcohol addiction.

Before having surgery, notify your doctor or dentist about all the products you use (for example prescription drugs, nonprescription drugs, and herbal products).

Minimize the use of alcohol. Regular use of alcohol may increase your chance for liver problems, particularly when combined with simvastatin. Ask your doctor/physician or pharmacist for further information.

Older adults can be more susceptible to the side effects of this drug, particularly muscle problems.

This medication must be avoided in pregnancy. Therefore, it is necessary to prevent pregnancy while taking this medication. Consult your doctor/physician for further details and to discuss the use of safe forms of birth control (for example condoms, birth control pills) while taking this medication. If you get pregnant or think you may be pregnant, notify your doctor/physician as soon as possible.

There is no information on whether this medication passes into breast milk. Breastfeeding while using this drug is not advised, because of the possible risk to the infant. Consult your doctor/physician before breastfeeding.

What are the drug interactions of Simvastatin?

Also, see how to Use section.

Drug interactions may alter how your medications act or increase your chance for severe side effects. This record does not have all possible interactions. Have a list of all the medicine you use (for example prescription/nonprescription drugs and herbal products) and inform it to your doctor and pharmacist. Do not start, stop, or adjust the dosage of any medicines without your doctor’s advice.

Some products may also interact with this drug such as danazol, gemfibrozil, “blood thinners” (such as warfarin) and cyclosporine.

Other medications can influence the removal of simvastatin from your body, which may affect the efficacy of simvastatin. Some of the examples include certain azole antifungals (such as itraconazole, voriconazole, ketoconazole, posaconazole), boceprevir, delavirdine, cobicistat, colchicine, macrolide antibiotics (such as clarithromycin, erythromycin), nefazodone, HIV protease inhibitors (such as nelfinavir, ritonavir), telaprevir and telithromycin.

Avoid taking any red yeast rice products while you are using simvastatin because some red yeast rice products may also have a statin known as lovastatin. Using simvastatin and red yeast rice products together can boost your risk of severe muscle and liver problems.


This drug must strictly be avoided during pregnancy.

Your risk of serious liver damage increases if you drink more than two drinks per day.

If you have any kidney problem may not be able to eliminate this drug from your body. This may cause the accumulation of this drug in your body and cause serious effects (such as muscle problems).

This drug can cause liver damage, which could lead to liver failure.

If you have hypothyroidism that is not well controlled, you may be at high risk for muscle problems when using this drug.

What are the forms and strengths of Simvastatin?

Generic: Simvastatin
Form: Oral tablet
Strengths: 5mg, 10mg, 20mg, 40mg, 80mg

Brand: Zocor
Form: Oral tablet
Strengths: 5mg, 10mg, 20mg, 40mg, 80mg

What is the dosage of Simvastatin?

For High Cholesterol:

Adult (18 years and older)

Usual starting dosage: Simvastatin is often started at 10–20mg per day. However, the dosage may range from 5mg to 40mg a day. You should take this drug once daily in the evening. Your doctor/physician will gradually adjust your dosage if needed.

Children (10–17 years)

Usual starting dosage: 10mg per day.

Note: Doses above 40mg per day have not been studied in this age group.

Children (0–9 years)

This medication is not studied in children below the age of ten years.

For reducing the chance of heart disease and heart attack and stroke in people with heart disease:

Adult (18 years and older)

Usual starting dosage: Simvastatin is mostly started at 10–20mg per day. However, the dose may range from 5mg to 40mg per day. You should take this drug once daily in the evening.

Dosage increases: Your doctor will gradually adjust your dosage if needed.


Children (10–17 years)

Usual starting dosage is 10mg per day.

Note: Doses above 40mg a day have not been studied in this age group.

Children (0–9 years)

This medication is not studied in children below age of 10 years.


TheMedPharma has made every effort to make sure that all the information is factually correct, comprehensive, and up-to-date. However, this website should not be considered as a substitute for the advice, knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or licensed health care professional before taking any medication. The drug information contained herein is subjected to changes if required. The lack of warnings or other information for a given drug does not mean that the drug or its combination is safe, effective or appropriate for use in all patients.