GENERIC NAME: Pindolol

COMMON BRANDS: Visken, Blocklin L, Calvisken, Decreten, Durapindol

Pindolol is an oral prescription drug belongs to a class of medications called non-selective beta-adrenoreceptor blockers. It is sold under the common brand name “Visken” used to treat high blood pressure.

Pindolol work by preventing adrenaline (norepinephrine) from acting on beta-adrenoreceptors that are present in blood vessels and the heart. This causes blood vessels to relax and slow down the heart rate to improve blood flow, decrease blood pressure and reduce strain on the heart.

What is Pindolol used for?

Hypertension:

This drug is used to treat hypertension in adults either alone or in combination with other antihypertensive medications (such as thiazide diuretics). Lowering blood pressure helps to prevent strokes, heart attacks, and kidney problems.

Angina pectoris:

This drug also used to treat angina (chest pain or pressure due to not enough blood flow to the heart muscle). Untreated angina can cause heart attack, heart failure, or arrhythmias (irregular heart rhythms).

How to use Pindolol?

Take pindolol tablet orally with food or without food, as directed by the doctor, usually taken 2 times a day. The dosage of this drug depends on your medical condition and response to the treatment.

To help you remember to take this drug at the same time each day. Carefully follow all the directions on your prescription label, and ask your doctor or pharmacist to explain any part you do not understand. Take pindolol exactly as directed. Do not alter your dose or take it more frequently than prescribed by your doctor.

Use this medication regularly as instructed by your doctor to get the most benefit from it. It is crucial to continue this drug even if you feel better. Many people with high blood pressure do not feel sick.

If you suddenly discontinue taking pindolol, you may experience serious heart problems like angina (chest pain) or heart attack.

You may have to wait for 1 to 2 weeks to observe the full benefit of this medicine. Inform your doctor if your medical condition remains unchanged or if it worsens (for example, if your blood pressure remains high or chest pain occurs more often).

What are the side effects of Pindolol?

The common side effects observed with the use of this drug include dizziness, lightheadedness, excessive tiredness, headache, difficulty sleeping, unusual dreams, stomach upset and muscle aches. If any of these effects remain or worsen, inform your doctor/pharmacist immediately.

Get up slowly from a sitting/lying position, as this may help to lessen the risk of dizziness and lightheadedness.

Pindolol may decrease the flow of blood to your hands and feet, causing them to feel cold. Avoid smoking or chewing of tobacco as this may worsen this effect.

Get emergency medical assistance right away if you notice any of the following severe side effects, such as signs of heart failure (breathlessness, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain), bluish color of the fingers/toes/nails, mental/mood changes (e.g., hallucination, confusion, depression, memory problems, many dreams), pain/cramps in the muscles/joints, numbness/tingling, decreased sexual ability, vision changes, slow/irregular/fast heartbeat, severe dizziness/fainting.

A severe allergic reaction to this drug is very rare. However, a severe allergic reaction that includes rashes, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing may occur. Get emergency medical assistance immediately if you notice any of the above side effects.

This is not a complete record of all possible side effects. Inform your doctor at the earliest, if you notice any of the side effects that are not mentioned in this article.

See also Warning and Precautions sections.

What are the precautions while using Pindolol?

Inform your doctor/pharmacist before taking pindolol, if you are allergic to it; or to any other beta-blockers (for example acebutolol, metoprolol, propranolol); or if you have other allergies. This drug may also contain some inactive ingredients that can cause allergic reactions or other problems. Talk to your doctor/pharmacist for further information.

Inform your doctor/pharmacist about all the products you are using including prescription, non-prescription, vitamins, nutritional supplements, and herbal products.

Before taking pindolol, tell your doctor/pharmacist about your medical history, mainly of blood circulation problems (like Raynaud’s disease, peripheral vascular disease), heart problems (like heart failure, heart attack, heart rhythm problems), kidney problems, liver problems, breathing problems (like asthma, chronic bronchitis, emphysema), low blood flow to the heart/brain (e.g., due to coronary artery disease, stroke, transient ischemic attack), mental/mood disorders (like depression, hallucination), a specific muscle disease (myasthenia gravis), hyperthyroidism, a certain type of tumor (pheochromocytoma) and severe allergic reactions.

This drug can make it difficult to control your blood sugar level. Monitor your blood sugar levels regularly share the results with the doctor. Notify your doctor quickly if you notice any symptoms of hyperglycemia (high blood sugar level) such as an increase in thirst or urination. Your doctor may recommend you exercises, diet or may adjust your diabetes medication.

If you have diabetes, pindolol may mask the symptoms of hypoglycemia (sudden fall in blood sugar level) such as fast/pounding heartbeat you would usually feel when you are hypoglycemic. Other symptoms of hypoglycemia such as sweating and dizziness, does not change by this drug.

This drug may cause you dizzy. Alcohol can make you dizzier. Avoid driving, use of machinery or doing anything that needs sharpness until you can do it safely. Limit alcoholic beverages.

An older adult is more sensitive to the side effects of this drug especially dizziness, due to impaired kidney and liver function.

During pregnancy, pindolol should be used only when benefits outweigh the risk. It may be harmful to the fetus. This drug can also cross into breast milk and for more information about the safety of drug talk to your doctor.

What are the drug interactions of Pindolol?

Pindolol may interact with other medications, herbs, or vitamins you may be using. A drug interaction is when a substance changes the way a drug works which can be harmful or hinder the drug from working well.

Do not start, stop, or alter the dose of the drug without discussing your doctor because your doctor may be monitoring you for possible drug interactions.

NSAIDs (such as diclofenac, ibuprofen, indomethacin, ketorolac, nabumetone, naproxen), a nasal decongestant (such as phenylephrine, pseudoephedrine), cough-and-cold products, may decrease the effectiveness of pindolol.

Some products may interact with pindolol such as alpha-blockers (prazosin), arbutamine, other beta-blockers (atenolol), clonidine, epinephrine, fenoldopam, fingolimod thioridazine and decrease its effectiveness.

Some medicines for high blood pressure (methyldopa), and drugs affecting liver enzymes (amiodarone, chlorpromazine, St. John’s wort) also interact with this drug.

Notify your doctor/pharmacist if you are taking other products that cause drowsiness such as alcohol, marijuana, drugs for sleep or anxiety (alprazolam, lorazepam, zolpidem), opioid pain medications or cough relievers (codeine, hydrocodone), muscle relaxants (carisoprodol, cyclobenzaprine), or antihistamines (cetirizine, diphenhydramine).

WARNINGS:

Stopping the drug:

Do not suddenly discontinue this medication without informing your doctor. Some conditions may become dangerous when you suddenly stop this drug. In some people who have abruptly terminated taking similar drugs have had chest pain, heart attack, and even irregular heartbeat. If your doctor recommends you to stop this drug, your doctor may ask you to reduce your dose gradually.

When you gradually decrease the dose of this drug before discontinuing this medication, your doctor may recommend you to restrict physical activity to reduce pressure on your heart. Get medical emergency assistance immediately if you notice symptoms such as chest pain/tightness/pressure, unusual sweating, trouble in breathing, chest pain spreading to the jaw/neck/arm, or fast/irregular heartbeat.

Pindolol is contraindicated in bronchial asthma, cardiac failure, cardiogenic shock, second and third-degree heart block, severe bradycardia (slow heart rate).

Other conditions:

Before taking pindolol, inform your doctor about all of your health conditions such as diabetes, chronic obstructive pulmonary disease (COPD), asthma, poor circulation, heart failure or other heart problems, hyperthyroidism.

What are the forms and strengths of Pindolol?

Form: Tablets
Strengths: 5mg, 10mg

What is the dosage of Pindolol?

For Hypertension (high blood pressure):

Adult (18–64 years):

Initial dose: Take 5mg orally twice daily. If the required increase dose by 10mg per day every 3 to 4 weeks.
Regular dose: Take orally 10 to 30mg per day in 2 to 3 divided doses.
Maximum dose: Dose should not exceed 60mg per day.

Children (0 to 17 years):

Avoid use of this drug in children below 18 years of age, as the studies have not been established yet.

Geriatric (65 years and older):

Initial dose: Take 5mg orally twice daily. If the required increase dose by 5mg per day every 3 to 4 weeks.

For Chronic Stable Angina (Off-label):

Adult (18–64 years):

Regular dose: Take orally 15-40 mg per day in divided every 6-8 hours.

Children (0 to 17 years):

Avoid use of this drug in children below 18 years of age, as the studies have not been established yet.

Geriatric (65 years and older):

For older adults, consider lower initial doses.

Special Dosage Considerations:

Hepatic impairment and renal impairment:

Pindolol is mainly metabolized in the liver and kidney dosage reduction is recommended for patients with severe hepatic impairment, or patients with hepatic disease and renal failure.

Most common questions asked about Pindolol / Q&A’s:

What are the serious side effects of Pindolol?

Seek a medical emergency as soon as possible if you experience these serious side effects such as difficulty breathing sore throat and fever, unusual bleeding, slow and irregular heartbeat, swelling of the feet or hands, weight gain and chest pain.

Disclaimer

TheMedPharma has made every effort to make sure that all the information is factually correct, comprehensive, and up-to-date. However, this website should not be considered as a substitute for the advice, knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or licensed health care professional before taking any medication. The drug information contained herein is subjected to changes if required. The lack of warnings or other information for a given drug does not mean that the drug or its combination is safe, effective or appropriate for use in all patients.