GENERIC NAME: Nisoldipine


Nisoldipine is an oral prescription drug, belongs to a class of medications known as calcium channel blockers. It works by reducing arterial blood pressure by vasodilation blood vessels throughout your body thereby reducing peripheral vascular resistance. This result in less pressure to built up and your heart does not have to work as hard to pump blood.

Nisoldipine is available in both brand-name version and generic-name version. Brand name version is available in extended-release tablet, and it is sold under the common brand “Sular“. The generic drug usually cost less.

What is Nisoldipine used for?


Nisoldipine is either used alone or in combination with other medications to treat high blood pressure. Lowering high blood pressure prevents strokes, heart attacks, kidney problems, loss of vision, and other problems.

How to use Nisoldipine?

Take this medication orally once per day or as directed by your doctor. Take this medication before food on an empty stomach or with a low-fat diet. Wait for at least 1 hour before or 2 hours after a high-fat meal. Doing so may increase side effects.

Swallow the whole extended-release tablets; do not split, chew, or crush them.

To help you remember to take this drug, take it at around the same time every day. Carefully follow all the directions on your prescription label and discuss with your doctor or pharmacist if you have any doubt.

Take nisoldipine exactly as instructed. Do not alter your dosage or take it more frequently than prescribed by your doctor.

The dose of the drug depends upon your medical examination and response to treatment. Your doctor may slowly increase your dose if needed.

Notify your doctor if your health does not improve or if it worsens (for example, your blood pressure remain high or increase, chest pain persists or worsens).

What are the side effects of Nisoldipine?

The commonly observed side effects with the use of this drug include dizziness or lightheadedness, a headache, flushing (reddening of the skin), edema (swelling in the legs or feet), nasal congestion, sore throat, weakness. Inform your doctor/pharmacist immediately, If any of these side effects continue or worsen.

To lower your danger of dizziness and lightheadedness, stand up slowly when rising from a sitting or lying position.

Seek medical help immediately if you see any severe side effects, including fast/irregular/pounding heartbeat, fainting, vision changes.

Get emergency medical assistance promptly, if you notice any of the following serious side effects like chest pain getting worse, symptoms of a heart attack (like chest pain radiating to jaw/left arm, shortness of breath, unusual sweating), low blood pressure or low heart rate (symptoms like lightheadedness, fainting), fast/irregular/pounding heartbeat especially at the beginning of treatment or increasing dose.

Severe allergic reaction to this drug is uncommon. However, get medical assistance help right away if you notice any symptoms of a severe allergic reaction, severe dizziness, rash, itching/swelling (especially of the face/tongue/throat), trouble breathing.

This file does not contain all possible side effects. Inform your doctor if you notice any of the side effects that are not mentioned in this article.

What are the precautions while using Nisoldipine?

Inform your doctor/pharmacist before taking Nisoldipine, if you are allergic to it; or if you have other allergies. This drug may also contain some inactive ingredients that can cause allergic reactions or other problems. Talk to your doctor/pharmacist for more information.

Inform your doctor/pharmacist about all the products you are using including prescription, non-prescription, vitamins, nutritional supplements, and herbal products.

Before taking this drug, tell your doctor or pharmacist about your medical history, mainly of liver problems, kidney problems, certain heart problems (such as congestive heart failure, aortic stenosis).

Avoid drinking grapefruit juice or eating grapefruit while taking nisoldipine as grapefruit increase nisoldipine concentration in blood this result in more side effects. Consult your doctor about taking grapefruit during treatment.

This drug may cause dizziness, do not drive, use machinery, or do anything that needs sharpness until you can do it cautiously. Limit use of alcoholic beverages. Speak to your doctor if you are using marijuana.

Older adults may be more likely susceptible to the side effects of this drug, mainly dizziness, and swelling of ankles/feet.

During pregnancy use this medication only when benefit outweighs the risk and for more information about the safety of drug talk to your doctor.

It is not clear whether this drug passes into breast milk. Consult your doctor before breastfeeding.

What are the drug interactions of Nisoldipine?

Nisoldipine may interact with other medications, herbs, or vitamins you may be taking. A drug interaction is when a drug changes the way a drug works which can either be harmful or stop the medicine from working well.

Do not discontinue or modify the dose of the drug without discussing with your doctor because your doctor may be monitoring you for potential drug interactions.

This drug interacts with anti-seizure medicine like phenytoin and carbamazepine and lowers the nisoldipine plasma concentrations to undetectable levels. This decreases the effectiveness of nisoldipine.

Some antifungal medicine like itraconazole, ketoconazole, posaconazole, voriconazole interacts with this drug and affects its elimination from your body, thereby affecting how nisoldipine works.

This drug interacts with cimetidine, imatinib, nefazodone, St. John’s wort and antibiotic-like clarithromycin, telithromycin.

NSAIDs (such as diclofenac, ibuprofen, naproxen), a nasal decongestant (such as phenylephrine, pseudoephedrine), cough-and-cold products, may decrease the effectiveness of nisoldipine.

This is not a complete list, and many other drugs can interact with nisoldipine.


Increased angina and heart attacks in patients with coronary artery disease:

A very few people with severe obstructive coronary artery disease, have developed increased frequency, duration and severity of angina, or heart attacks at the start of the nisoldipine therapy or at the time of dosage increase.

What are the forms and strengths of Nisoldipine?

Generic: Nisoldipine
Form: Oral extended-release tablet
Strengths: 8.5mg, 17mg, 20mg, 25.5mg, 30mg, 34mg, 40mg

Brand: Sular
Form: Oral extended-release tablet
Strengths: 8.5mg, 17mg, 34mg

What is the dosage of Nisoldipine?

For Hypertension (high blood pressure):

Adult (18 to 64 years):

Slow release (old formulation):

Initial dose: Take 20mg orally once a day
Maintenance dose: 10 to 60mg orally once a day
Maximum dose: Do not exceed 60mg/day

Controlled release (new formulation):

Initial dose: Take 17mg orally once a day
Maintenance dose: 8.5 to 34mg orally once a day
Maximum dose: Do not exceed 34mg/day


Children (0 to 17 years):

Avoid use of this drug in children below 18 years of age, as the studies have not been established yet.

Geriatric (65 years and older):

Slow release (old formulation):

Initial dose: Take 10mg orally once a day
Maintenance dose: 10 to 60mg orally once a day
Maximum dose: Do not exceed 60mg/day

Controlled release (new formulation):

Initial dose: Take 8.5mg orally once a day
Maintenance dose: 8.5 to 34mg orally once a day
Maximum dose: Do not exceed 34mg/day

Special Dosage Considerations:

Hepatic impairment and renal impairment:

Nisoldipine is mainly metabolized in the liver, and kidney dosage reduction is recommended for patients with severe hepatic impairment, or patients with hepatic disease and renal failure.

Most common questions asked about Nisoldipine / Q&A:

What are the serious side effects of Nisoldipine?

Some of the serious side effects of Nisoldipine may include swelling of the face/eyes/lips/tongue/arms/legs, difficulty breathing or swallowing, fainting and rashes. Seek a medical emergency as soon as possible if you experience any of these effects.


TheMedPharma has made every effort to make sure that all the information is factually correct, comprehensive, and up-to-date. However, this website should not be considered as a substitute for the advice, knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or licensed health care professional before taking any medication. The drug information contained herein is subjected to changes if required. The lack of warnings or other information for a given drug does not mean that the drug or its combination is safe, effective or appropriate for use in all patients.