GENERIC NAME: Lurasidone

COMMON BRANDS: Latuda, Lurace, Lurafic, Luramax, Lurasid

Lurasidone is an oral prescription medicine belongs to a class of drugs known as atypical antipsychotics. Lurasidone is a second-generation antipsychotic drug, which is considered a standard drug for the treatment of schizophrenia, like other drugs of this class such as clozapine, risperidone, aripiprazole, and ziprasidone. This drug is effective in improving mood in many people with bipolar depression. This drug can be taken alone or in combination with lithium (Lithobid) or sodium valproate (Depakine).

The clear mechanism of action of lurasidone is unknown. It may work by inhibiting several neurotransmitter receptors (such as dopamine and serotonin type 2 (5-HT2) receptors) in the brain.

FDA approved lurasidone in July 2012 for the treatment of depressive episodes associated with bipolar I disorder.

What are the uses of Lurasidone?

Lurasidone is used for the treatment of schizophrenia in adults and children 13 years of age and older. This drug is also used to treat depression associated with bipolar disorder in adults and children 10 years of age and older. This drug helps to decrease hallucinations and may improve your mood, sleep, appetite, and energy level.

How to use Lurasidone?

Take this drug orally with a meal as directed by your doctor, once daily. Follow all instruction on your prescription label carefully, and seek advice from your doctor/pharmacist if you have any doubt or you do not understand any part. Take lurasidone exactly as directed at around the same time every day. Do not alter your dose or take it more often than prescribed by your doctor.

This drug helps to control schizophrenia and depression in people with bipolar disorder, but it does not cure these conditions. It may need some weeks or longer before you get the full benefit of lurasidone. Take this drug regularly even if you feel better. Do not stop taking lurasidone without consulting your doctor.

Avoid eating grapefruit with this drug as it may increase the risk of side effects. Discuss with your doctor or pharmacist for more details. Inform your doctor if your condition remains the same or if it worsens.

What are the side effects of Lurasidone?

The most common side effects with this drug include drowsiness, dizziness, restlessness, lightheadedness, difficulty in moving, slow movements, muscle stiffness, tremor, weight gain and nausea. Seek medical assistance promptly, if any of these side effects remain or worsen.

Inform your doctor immediately if any of these severe side effects occur like Involuntary movements of the tongue, face or other body parts (tardive dyskinesia), hyperglycemia (high blood sugar), high level of cholesterol and triglyceride. A sudden drop in white blood cell count and difficulty swallowing, fainting, interrupted breathing during sleep.

This drug may cause a sudden decrease in blood pressure especially when rising too quickly from a sitting or lying position.

It is very uncommon that this drug may increase prolactin level in both male and female. This high level of hormone (prolactin) in women may result in unwanted breast milk, missed/stopped periods, or difficulty in getting pregnant. For men, it may result in decreased sexual ability, inability to produce sperm, or gynecomastia (enlargement of breasts). If any of these symptoms develop, inform your doctor immediately.

This drug may increase the risk of stroke which can be fatal in elderly patients with dementia. Lurasidone linked with an increased risk of suicidal thoughts especially in children, teenagers, and young adults within the first few months of treatment. Neuroleptic malignant syndrome or NMS, a rare but severe condition caused by antipsychotic medicines includes symptoms like fever, severe tiredness, severe confusion, muscle stiffness/pain/tenderness/weakness, sweating, fast/irregular heartbeat, signs of kidney problems (like a change in the amount of urine, dark urine).

This is not a full record of all possible side effects. If you mark other effects not listed above, contact your doctor or pharmacist.

What are the precautions while using Lurasidone?

See also Warning section.

Before taking lurasidone, inform your doctor/pharmacist if you are allergic to it; or if you have any other allergies. This product containing lurasidone may contain some other inactive ingredients, which can induce allergic reactions or other serious problems. Talk to your pharmacist for further details.

Short-term studies show that antidepressants can induce suicidal thoughts and behavior in pediatric and young adults. Monitor closely for clinical worsening or emergence of suicidal thoughts and behaviors

Inform your doctor or pharmacist about your complete medical history before using this medication, especially if you are suffering from any liver problems, kidney problems, stroke, breast cancer, diabetes (including family history), obesity, low blood pressure, seizures, low white blood cell (WBC) count, dementia (such as Alzheimer’s), breathing difficulty during sleep (sleep apnea), trouble swallowing.

This drug may cause drowsiness. Avoid driving or use of machinery, or perform any activity that needs alertness. Avoid alcoholic beverages. Talk to your doctor whether or not you can perform any such activity.

Before undergoing any surgery, Inform your doctor or dentist if you are using any herbal products, prescription, or nonprescription.

This medication may cause you to sweat less, making you prone to heat stroke. Avoid doing things that may need more hard work, heat exposure. Drink lots of water or fluids and avoid wearing warm clothes. If you are exposed to heat such as hot weather, find shade or way to cool yourself to prevent any severe effects. If you have a fever, headache, dizziness, or mood changes get medical help immediately.

Older adults may be at higher risk of side effects of this drug, especially drowsiness, dizziness, and lightheadedness, as it may increase the chances of falling that can inflict severe injury.

Inform your doctor if you are pregnant or planning to get pregnant, before starting or while using this medication. There are no established studies that show whether this medication passes into breast milk. Consult your doctor before breastfeeding.

Avoid using this drug in the last three months of pregnancy, unless your doctor advises you to use, as it is observed that babies born to mothers using this drug in the last three months of pregnancy have problems like shakiness, breathing problems, muscle stiffness, or constant crying. If you observe any such behaviour in your newborn below one month, seek medical attention immediately.

What are the drug interactions of Lurasidone?

Also, see how to use.

This record does not have all the possible drug interactions. Keep a list of all prescription, nonprescription and herbal products that you use and share it with your doctor and pharmacist. Do not start, stop, or alter the dosage of any medication without your doctor’s approval.

Avoid using lurasidone along with strong CYP3A4 inducers like rifampin (Rimactane), St. John’s Wort, carbamazepine (Tegretol), and phenytoin (Dilantin) because the concentration of lurasidone in the blood may decrease, resulting in poor treatment results. If moderate CYP3A4 inducers are used more than a week, the dose of lurasidone may need to be increased.

Avoid using lurasidone along with strong CYP3A4 inhibitors like ketoconazole (Nizoral), clarithromycin (Biaxin), mibefradil (Posicor), ritonavir (Norvir), voriconazole (VFEND), and many other drugs because the concentration of lurasidone in the blood may increase. Grapefruit and grapefruit juice must be avoided in patients taking lurasidone, as it may inhibit CYP3A4 enzymes.

Some medications can alter the excretion of lurasidone from your body, which can alter the effectiveness of the treatment with lurasidone. Some of the examples are azole antifungals (like ketoconazole, itraconazole), diltiazem, macrolide antibiotics (like clarithromycin), certain HIV/hepatitis C virus protease inhibitors (like atazanavir, boceprevir, ritonavir), antidepressants (like fluoxetine, paroxetine, nefazodone), rifamycin (like rifampin, rifabutin), telithromycin.

Inform your doctor if you are using products that can induce drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), antihistamines (such as cetirizine, diphenhydramine), alcohol, marijuana, muscle relaxants (such as carisoprodol, cyclobenzaprine), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem).

Read the labels of all your medicines such as allergy or cough-and-cold products because they may contain ingredients which can cause drowsiness. Ask your pharmacist for further details to use the drug safely.

WARNINGS:

This drug may sometimes increase the risk of serious, possibly fatal side effects (like pneumonia, stroke, heart failure, fast/irregular heartbeat) when taken by older adults with dementia. This drug is not approved for the treatment of behavioural problems associated with dementia. Talk to your doctor regarding the risks and benefits of this medicine and other safer treatments available for behaviour problems associated with dementia.

Lurasidone is used for the treatment of certain mental/mood disorders (such as schizophrenia, depression related bipolar disorder). Most of the medicines used to treat depression can be used to prevent suicidal thoughts/attempts. However, studies have shown that few people (especially below 25 years) who take drugs to treat depression may experience worsening of depression, sudden mood change, or suicidal thoughts. This is the reason that you must always remember to talk to your doctor if you observe any of these symptoms.

What are the forms & strengths of Lurasidone?

Form: Tablet
Strengths: 20mg, 40mg, 80mg, 120mg.

What is the dosage of Lurasidone (Latuda)?

For Schizophrenia:

Adult

Initial dose: 40mg orally once a day.
Maintenance dose: 40-160mg orally per day.
Maximum dose: 160mg/day.

Pediatric

Children (13 to 17 years):

Initial dose: 40mg orally once a day.
Maintenance dose: 40 to 80mg orally per day.
Maximum dose: 80mg per day.

For Bipolar Disorder:

Adult

Initial dose: 20mg orally once a day.
Maintenance dose: 20mg-120mg orally once a day.
Maximum dose: 120mg/day.

Monotherapy treatment: Major depressive episodes associated with bipolar I disorder (bipolar depression). In monotherapy, efficacy in the lower dose range of 20-60mg per day was on average, comparable to higher doses of 80mg-120mg.

Adjunctive treatment: Along with lithium or valproate in patients with major depressive episodes associated with bipolar I disorder (bipolar depression).

Pediatric

Children (10 to 17 years):

Initial dose: 20mg orally once a day.
Maintenance dose: 20mg to 80mg orally once a day.
Maximum dose: 80mg per day.

The dose can be increased after 1 week based on response to the treatment.

Monotherapy: Efficacy in the lower dose range from 20-40mg per day were on average, comparable to doses up to 80mg.

Dose Modifications:

Renal dose modifications:

Mild renal impairment (CrCl 50mL/min or higher):

Adjustment not recommended.

Moderate to high renal impairment (CrCl less than 50mL/min):

Initial dose: 20mg orally once a day.
Maximum dose: 80mg per day.

Liver dose modifications:

Mild liver dysfunction (child-pugh below 7):

No modifications are recommended.

Moderate liver dysfunction (child-pugh 7 to 9):

Initial dose: 20mg orally once a day.
Maximum dose: 80mg per day.

Severe liver dysfunction (child-pugh 10 to 15):

Initial dose: 20mg orally once a day.
Maximum dose: 40mg per day.

Disclaimer

TheMedPharma has made every effort to make sure that all the information is factually correct, comprehensive, and up-to-date. However, this website should not be considered as a substitute for the advice, knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or licensed health care professional before taking any medication. The drug information contained herein is subjected to changes if required. The lack of warnings or other information for a given drug does not mean that the drug or its combination is safe, effective or appropriate for use in all patients.