GENERIC NAME: Lisinopril

COMMON BRANDS: Zestril, Prinivil, Qbrelis

Lisinopril is a prescription drug, belongs to a class of drugs known as “angiotensin-converting enzyme (ACE) inhibitors.” It is an oral drug that’s used to treat hypertension (high blood pressure) and heart failure. It is also used to improve your chances of survival after a heart attack. This drug may be prescribed alone or with other medications.

Typically the starting dose for adults with high blood pressure is 10 mg once a day. Your doctor/physician may increase your dose to a maximum of 80 mg a day. The initial starting dose for adults with heart failure is 5 mg a day. Your doctor/physician may increase your dose up to a maximum of 40 mg a day.

What are the uses of Lisinopril?

Lisinopril is used for the treatment of high blood pressure. Reducing high blood pressure prevents heart attacks, strokes, and kidney problems. It is used in the treatment of heart failure and improves survival after a heart attack.

How to use Lisinopril?

Take this medication orally with or without meals as directed by your doctor/physician, usually once a day.

Shake well before each dose, if you are using the suspension form. Dose has to be measured using a special measuring spoon.

The dosage depends on your medical diagnosis and treatment response. For children, the dosage depends on body weight.

Hypertension (high blood pressure) treatment may take 2 to 4 weeks before you observe the full benefit of this medication. In the treatment of heart failure, it may take weeks to months before you get the full benefit from this medication. Inform your doctor/physician if there is no improvement in your condition or if it gets worse (such as your blood pressure readings remain constant or increase).

To lessen your risk of side effects, your doctor/physician may advise you to start this medication at a low dose initially and gradually increase your dose. Follow your doctor’s guidance carefully.

Use this medication without missing to get the most benefit from it. To make sure you don’t forget, take it at the same time each day. Take this medication even after you feel well. Many people with high blood pressure do not feel sick/weak.

What are the side effects of Lisinopril?

Some of the side effects like lightheadedness, dizziness, tiredness or a headache may occur as your body adjusts to the medication. A persistent dry cough may also occur. If any of these effects remain or become worse, inform your doctor/physician/pharmacist quickly.

To minimize the risk of lightheadedness and dizziness, get up slowly when rising from a sitting position or lying position. Remember that your doctor/physician has prescribed this medication because he or she has found that the benefits are higher than the chance of side effects. Most of the people using this medication do not experience serious side effects.

Inform your doctor/physician immediately if you have any severe side effects including fainting, symptoms of a high potassium level (for example muscle weakness and slow or irregular heartbeat).

Although lisinopril is taken to prevent kidney problems or treat people who suffer from kidney problems, it may also rarely produce severe kidney problems or make them dangerous. Your doctor/physician will test your kidney function while you are taking lisinopril. Tell your doctor/physician immediately if you experience any symptoms of kidney problems like a change in the amount of urine.

Lisinopril may sometimes cause serious (possibly fatal) liver problems. Get medical assistance as soon as possible if you have any symptoms of the liver problem, such as non-stop nausea/vomiting, dark urine, loss of appetite, stomach/abdominal pain or yellowing eyes/skin.

A severe allergic reaction to this drug is uncommon. However, get medical help quickly if you mark any symptoms of a severe allergic reaction such as rash, itching/swelling (particularly of the face/tongue/throat), trouble breathing or severe dizziness.

This record does not contain the full list of all possible side effects. If you mark other effects not listed above, contact your doctor/physician/pharmacist.

What are the precautions while using Lisinopril?

Before taking lisinopril, inform your doctor/physician/pharmacist if you are allergic to it, or to any other ACE inhibitors (for example benazepril) or if you have other allergies. This product may consist some inactive ingredients, which can produce allergic reactions or other problems. Ask your pharmacist for further details.

Before using this medication, inform your doctor/physician/pharmacist about your medical history, especially of the history of an allergic reaction which involved swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (for example LDL apheresis, dialysis) or high level of potassium in the blood.

This drug may cause you dizzy. Alcohol or marijuana can make you dizzier. Avoid driving, use of machinery or doing anything that needs sharpness until you can do it safely. Limit alcoholic beverages. Speak to your doctor/physician if you are using marijuana.

Too much sweating, diarrhea or vomiting may make the loss of too much body water and increase your chance of lightheadedness. Inform your doctor/physician if you have prolonged diarrhea or vomiting. Make sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

Before having any surgery, notify your doctor or dentist about all the products you use (such as prescription drugs, nonprescription drugs, and herbal product).

This product may raise your potassium levels in the body, before using potassium supplements or salt substitutes that consist of potassium, ask your doctor/physician/pharmacist.

Older adults could be more susceptible to the side effects of this drug, especially dizziness and increase in potassium level.

This medication is not advised for use throughout the pregnancy. It may harm an unborn baby. Ask your doctor/physician for further details. (See also Warning.)

There is no information whether or not this medication passes into breast milk. Ask your doctor/physician before breastfeeding.

What are the drug interactions of Lisinopril?

See also Precautions.

Drug interactions may alter how your medications work or increase your chance for severe side effects. This section does not contain the full list of all possible drug interactions. Have a list of all the products you use (for example prescription/nonprescription drugs and herbal products) and inform it to your doctor/physician/pharmacist. Do not start, stop, or adjust the dosage of any medicines without your doctor’s advice.

Some examples of products that may interact with this drug are: aliskiren, lithium, certain medicines that decrease the immune system/increase the risk of infection (such as everolimus, sirolimus), drugs that may increase the potassium levels in the blood (for example ARBs including birth control pills containing drospirenone, losartan/valsartan), sacubitril.

Some products may contain ingredients that could raise your blood pressure or increase the risk of heart failure. Tell your doctor/physician/pharmacist what products you are using, and ask how to use them safely (particularly cough-and-cold products, NSAIDs such as ibuprofen/naproxen, diet aids).

A reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) along with lisinopril. Make sure all your doctors know about medicines you are using.

WARNINGS:

This medication may inflict serious (possibly fatal) harm to a fetus if used during pregnancy. It is critical to prevent pregnancy while taking this medication. Consult your doctor/physician for further details and to consider the use of reliable forms of birth control while taking this medication. If you have plans for pregnancy or become pregnant or think you may be pregnant, notify your doctor/physician immediately.

What are the forms and strengths of Lisinopril?

Brand: Prinivil
Form: Oral tablet
Strengths: 2.5mg, 5mg, 10mg, 20mg, 30mg, 40mg

Brand: Zestril
Form: Oral tablet
Strengths: 5mg, 10mg, 20mg

What is the dosage of Lisinopril?

For High Blood Pressure (hypertension):

Adult dosage (18–64 years):

Starting dose: 10mg taken by mouth once a day
Usual dose: 20–40mg taken once a day
Maximum dose: 80mg taken once a day

Pediatric:

Children (6–17 years):

Starting dose: 0.07mg/kg of body weight taken by orally once a day.
Dose adjustments: depend on your blood pressure.
Maximum dose: 0.61mg/kg up to 40 mg, once a day.

Children (ages 0–5 years):

This medicine is not studied and shouldn’t be given to children below 6 years.

Geriatric (ages 65 years and above):

The kidneys of older people may not work efficiently, and this can cause your body to metabolize drugs slowly. As a result, more of a drug remains in your body. This increases the chances for side effects.

Your doctor/physician may prescribe you a lower dosage initially or a different schedule. This can help maintain normal levels of this drug in your body.

For Heart Failure:

Adult dosage (ages 18–64 years):

Starting dose: 5mg taken by mouth once per day
Maximum dose: 40mg taken once per day

Pediatric:

Children (ages 0–17 years):

This medicine is not studied and must be avoided in children younger than 18 years for heart failure.

Geriatric (65 years and older):

The kidneys of older people may not work efficiently, and this can cause your body to metabolize drugs slowly. As a result, more of a drug remains in your body. This increases the chances for side effects.

Your doctor/physician may prescribe you a lower dosage initially or a different schedule. This can help maintain normal levels of this drug in your body.

For Acute Myocardial Infarction (heart attack):

Adult dosage (18–64 years):

Starting dose: 5mg taken by mouth within the first 24 hours of when symptoms of heart attack start. Your doctor will give you another 5mg after another 24 hours.
Usual dose: 10mg given 48 hours after a heart attack. Then 10mg taken once per day for at least six weeks.

Pediatric:

Children (6–17 years):

This medicine hasn’t been studied in children below 18 years for improving survival after a heart attack.

Children (0–5 years):

This medicine must be avoided in children below 6 years.

Geriatric (65 years and older):

The kidneys of older people may not work efficiently, and this can cause your body to metabolize drugs slowly. As a result, more of a drug remains in your body. This increases the chances for side effects.

Your doctor/physician may prescribe you a lower dosage initially or a different schedule. This can help maintain normal levels of this drug in your body.

Special Case:

Heart failure: If you are tested for low blood sodium levels, your starting dose may be 2.5mg taken once a day.
Improving survival after having a heart attack: If you are tested for low blood pressure, your starting dose may be 2.5mg once a day for the first three days after having a heart attack.

Disclaimer

TheMedPharma has made every effort to make sure that all the information is factually correct, comprehensive, and up-to-date. However, this website should not be considered as a substitute for the advice, knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or licensed health care professional before taking any medication. The drug information contained herein is subjected to changes if required. The lack of warnings or other information for a given drug does not mean that the drug or its combination is safe, effective or appropriate for use in all patients.