GENERIC NAME: Lansoprazole

COMMON BRANDS: Prevacid

Lansoprazole is an oral prescription drug that belongs to a class of medication known as proton pump inhibitors (PPI’s). It acts by inhibiting (blocking) the excess release of acid in your stomach. It is available as an oral capsule form and oral tablet form, which is a delayed-release drug (releases slowly in the stomach), with brand-name “Prevacid”.

What is Lansoprazole used for?

Lansoprazole is used for the treatment of specific stomach and esophagus problems (such as acid reflux, ulcers). It acts by reducing the excess amount of acid production in your stomach. It helps in relieving symptoms such as heartburn, difficulty swallowing, and a persistent cough. This medication helps heal stomach and esophageal damage caused by excessive stomach acid, thereby preventing ulcers, and also prevent the development of esophageal cancer.

Lansoprazole is used for the treatment of certain conditions such as:

    • Gastroesophageal reflux disease (GERD) – Acid reflux occurs when stomach contents move backward toward the esophagus.
    • Erosive esophagitis -Esophagus damage caused by excess acid.
    • Gastric ulcers (stomach ulcers) or duodenal ulcers (ulcers on the upper part of small intestine).
    • Zollinger-Ellison syndrome (ZES) – A rare condition characterized by the formation of tumors on the digestive tract (especially duodenum).
    • Helicobacter pylori – Stomach infections caused by bacteria.
    • This drug also prevents stomach ulcers caused by excessive use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Prescription lansoprazole is used alone or in combination with other medications for the treatment of stomach ulcers caused by the bacteria (H. pylori) in adults.

Nonprescription (over-the-counter) lansoprazole is used for the treatment of frequent heartburn that occurs two or more days per week in adults.

How to use Lansoprazole?

Before you start your treatment with Lansoprazole, and each time you get a refill, read the patient information guideline if available from your pharmacist.

Take this medication once a day orally, on an empty stomach, at least an hour before meals. If you are on self-medication, follow the product package information. The treatment depends on your medical condition and treatment response. Avoid increasing your dose or taking it frequently unless your doctor’s recommendation. Ask your doctor/pharmacist for further information.

If you are taking sucralfate or any antacids, take Lansoprazole at least 30 minutes before taking sucralfate or antacid. Swallow the capsule whole without breaking, crushing or chewing.

If you are using oral disintegrating tablets, do not break, cut or chew the tablets. Place a tablet in your mouth and wait for it to dissolve. After the tablet dissolves, swallow as such or with water. If you have difficulty in swallowing the tablet, place it in an oral syringe. For a 15 mg tablet, draw approximately 4 mL of water or about 10 mL of water for a 30 mg tablet. Shake the syringe to dissolve the tablet and squirt the contents into your mouth instantly. Then draw an extra 2 mL of water into the syringe, shake well, and squirt that water into your mouth. Do not swallow if the mixture was prepared more than 15 minutes ago.

Take this drug regularly to get the full benefit from it. Preferably take this medicine at the same time each day to avoid missing any dose.

Continue this medication even if you feel better until the course of the treatment is completed. If you are using the over-the-counter product and you are on self-medication, do not exceed the medication for more than 2 weeks.

Ask your doctor, if your condition does not improve or if it gets worse even after self-medication of 2 weeks. The risk of side effects increases by time. Ask your doctor about how long you should use this medication.

What are the side effects of taking Lansoprazole?

The side effects of Lansoprazole are slightly different for children and adults.

The common side effects observed in an adult such as a headache, diarrhea, nausea, flatulence (passing gas), constipation, stomach pain, and dry mouth. Whereas in children’s side effects consist of the above, plus regurgitation (burping up food) in babies, increased breathing rate in babies. Take your doctor’s advice if any of these side effects continue or worsen.

Using this drug for a prolonged duration more than three years can make vitamin B-12 absorption difficult, resulting in vitamin B-12 deficiency. Symptoms of vitamin B-12 deficiency such as neuritis (inflammation of a nerve), poor muscular coordination, nervousness, tingling or numbness in hands and feet and changes in menstruation may occur.

Get medical assistance promptly if you notice any severe side effects, such as signs of lupus (like a rash on nose and cheeks, new or worsening joint pain), symptoms of a low magnesium blood level (like an unusually fast/slow/irregular heartbeat, persistent muscle spasms, seizures).

This drug rarely causes a severe intestinal infection caused by Clostridium difficile (a type of bacteria). Avoid using any anti-diarrhoea opioid medications as these products may make them worse. Tell your doctor right away if you observe symptoms such as stomach pain/cramping, persistent diarrhoea, fever, blood/mucus in your stool.

Allergic reaction to this medicine is very rare. However, get medical help promptly if you notice any symptoms of a severe allergic reaction, itching/swelling (face/tongue/throat), such as rash, breathlessness, irregular, fast, or pounding heartbeat.

This is not a full record of all possible side effects. If you mark other effects not listed above, contact your doctor or pharmacist.

What are the precautions while using Lansoprazole?

Before using this lansoprazole, inform your doctor or pharmacist if you are allergic to it or any other proton pump inhibitors or if you have any other allergies.

Discuss with your doctor about medical history, mainly of liver disease, kidney problems, or lupus (an autoimmune disease).

Get medical assistance promptly if you have heartburn with dizziness/lightheadedness/sweating, chest pain radiating to jaw/arm/shoulder (especially with shortness of breath, unusual sweating), sudden unexplained weight loss.

If you are using this medication as over-the-counter, get medical help right away if you notice any of these signs of a severe condition like blood in vomit, vomit that looks like coffee grounds, pain/trouble swallowing food, recurrent wheezing (especially with heartburn), bloody/black stools, heartburn for over 3 months, frequent chest pain, nausea/vomiting, abdominal pain.

Lansoprazole like other proton pump inhibitors may increase your risk of bone fractures, mainly when used for a more extended period, higher doses, and in older adults. Talk with your doctor or pharmacist about how to prevent bone loss/fracture, such as by taking calcium and vitamin D supplements.

In pregnancy, use this drug only when benefits outweigh the risk. Discuss with your doctor for further details about the risks and benefits.

This medication may cross into breast milk. The effects of this drug are unknown on a nursing infant. Consult your doctor before breastfeeding.

What are the drug interactions of Lansoprazole?

Lansoprazole may interact with other medications, herbs, or vitamins you may be using. A drug interaction is when a substance changes the way a drug works which can be harmful or hinder the drug from working well.

Do not start, stop, or alter the dose of the drug without discussing your doctor because your doctor may be monitoring you for possible drug interactions.

Hypomagnesemia (low blood magnesium levels) may occur with prolonged use (more than 1 year). Report any incidence of hypomagnesemia symptoms such as arrhythmias, tetany, and seizures to the doctor. Magnesium supplementation alone did not help to maintain serum magnesium levels, and the PPI need to be discontinued. Regular monitoring is advised for patients taking lansoprazole in such cases.

Lansoprazole may interact with some medications like clopidogrel, cilostazol, methotrexate (at high-dose treatment), rifampin, St John’s wort.

Some medications need stomach acid to absorb them properly in the body. Lansoprazole decreases stomach acid so it may hinder work of these products. Some of the affected medicines like nelfinavir, pazopanib, atazanavir, erlotinib, rilpivirine, certain azole antifungals (ketoconazole, itraconazole, posaconazole), among others.

Lansoprazole is very similar to other proton pump inhibitors. Do not use any medications containing Lansoprazole with this drug.

This medication may intervene with specific lab tests, resulting in a false test. Assure that all your doctors and lab personnel know you use this drug.

WARNINGS:

Allergy: Lansoprazole can cause a severe allergic reaction in some people Such as rashes, face swelling, throat tightness or trouble breathing. Call an emergency if notice any of these effects.

Pregnant women: There are no studies on pregnant women that prove this drug is safe in pregnancy. Notify to your doctor before using this drug if you are pregnant.

Breastfeeding women: Lansoprazole passes into breast milk. Inform your doctor if you breastfeed. You may need to choose whether to stop taking this medication or stop breastfeeding.

For children: Avoid using this drug in children below 16 years as the studies are not established yet in this age group.

For seniors: The dose of the drug depends on your kidney function as with the ageing kidney function decrease, and your body may metabolise this drug more slowly. At the start of therapy, the doctor may prescribe you lowe dose to avoid too much of gabapentin in your body which can be dangerous.

What are the forms and strengths of Lansoprazole?

Generic: Lansoprazole
Form: Oral delayed-release capsule
Strengths: 15 mg, 30 mg

Brand: Prevacid.
Form: Oral delayed-release capsule
Strengths: 15 mg, 30 mg

Form: Oral delayed-release tablet
Strengths: 15 mg, 30 mg

What is the dosage of Lansoprazole?

For Duodenal Ulcers:

Adult dosage (18 and older):

Typical dosage: 15mg taken once a day for four weeks. Your doctor may prescribe you this drug for a more extended period for continued healing of your ulcer.

Children (0–17 years):
Lansoprazole has not been studied in children younger than 18 years. It should not be used in this age group.

For Gastric Ulcers (stomach ulcers):

Adult dosage (18 and older):

Typical dosage: 30mg taken once a day for up to 8 weeks.

Children (0–17 years):

Lansoprazole has not been studied in children younger than 18 years. It should not be used in this age group.

For Gastric Ulcers from NSAIDs:

Adult dosage (18 and older):

For short-term treatment: 30mg taken once per day for 8 weeks.
For prevention: 15mg taken once per day for up to 12 weeks.

Children (0–17 years):

Lansoprazole has not been studied in children younger than 18 years. It should not be used in this age group.

For Erosive Esophagitis (EE):

Adult dosage (18 and older):

For short-term treatment: 30mg taken once per day for up to 8 weeks.
For maintenance: 15 mg taken once per day.

Children (12–17 years):

Typical dosage: 30mg taken once per day for up to 8 weeks.

Children (1–11 years):

It isn’t known if this drug safe to use this drug for longer than 12 weeks in children of this age range for the treatment of erosive esophagitis.

Children (below 30 kg or 66 lbs): 15mg once per day for 12 weeks.
Children (above 30 kg or 66 lbs): 30mg once per day for 12 weeks.

Children (0–11 months):

Lansoprazole has not been studied in children younger than 1 year.

For Gastroesophageal Reflux Disease (GERD):

Adult dosage (18 and older):

Typical dosage: 15mg taken once per day for up to 8 weeks.

Children (12–17 years):

Typical dosage: 15mg taken once per day for up to 8 weeks.

Children (1–11 years):

It isn’t known if this drug safe to use this drug for longer than 12 weeks in children of this age group for the treatment of GERD.

Children (below 30 kg or 66 lbs.): 15mg taken once a day for up to 12 weeks.
Children (below 30 kg or 66 lbs.): 30mg taken once a day for up to 12 weeks.

Children (0–11 months):

Lansoprazole has not been studied in children younger than 1 year.

For Hypersecretory Conditions:

Adult dosage (18 and above):

Typical starting dosage: 60mg taken once per day.

Dosage increases: Your doctor will adjust your dosage as needed. If you’re taking more than 120mg per day, your doctor will have you take this drug in divided doses.

Children (0–17 years):

Lansoprazole has not been studied in children younger than 18 years. It should not be used in this age group.

For Helicobacter pylori (H. pylori) stomach infections:

Adult dosage (18 and older):

Triple therapy dosage: If you’re taking this drug with amoxicillin and clarithromycin, take 30mg of this drug twice per day (every 12 hours) for 10 or 14 days.
Dual therapy dosage: If you’re taking this drug with only amoxicillin, take 30mg of this drug three times per day (every 8 hours) for 14 days.

Children (0–17 years):

Lansoprazole has not been studied in children younger than 18 years. It should not be used in this age group.

Most common questions asked about Lansoprazole / Q&A’s:

Do I have to take Lansoprazole on an empty stomach?

Yes, lansoprazole must be taken in the morning on an empty stomach to get the maximum benefits from this drug. The maximum absorption of this drug takes place in the acidic pH which is present in an empty stomach. Presence of food in stomach dilutes the stomach acid and reduces the absorption of this drug. The studies show taking lansoprazole up to 30 minutes after eating meals decreased the peak levels of the drug in the blood by 50 percent. Most of the proton pump inhibitors are ineffective because people do not follow the instructions correctly.

Is Omeprazole the same as Lansoprazole?

Well, that depends on what precisely the similarities you are looking for in omeprazole and lansoprazole. If we talk about the similarities they both as same when it comes to the mechanism of action and they both belong to the same class of drugs known as proton pump inhibitors (PPI’s). When it comes to the differences, they both are different in the chemical structure and potency, duration of action and onset of action.

Disclaimer

TheMedPharma has made every effort to make sure that all the information is factually correct, comprehensive, and up-to-date. However, this website should not be considered as a substitute for the advice, knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or licensed health care professional before taking any medication. The drug information contained herein is subjected to changes if required. The lack of warnings or other information for a given drug does not mean that the drug or its combination is safe, effective or appropriate for use in all patients.