GENERIC NAME: Fosinopril
COMMON BRAND: Monopril
Fosinopril is an oral prescription drug, belongs to a class of drugs known as “angiotensin-converting enzyme (ACE) inhibitors.” It acts by hindering the activity of the enzyme ACE and decreases the production of angiotensin II (very potent vasoconstrictor that causes blood vessels to constrict, thereby narrowing the vessels. The narrowing of the blood vessels increases the pressure within the vessels causing high blood pressure). This drug dilates blood vessels, thereby decreasing blood pressure and makes it easier for the heart to pump blood and increase blood flow to kidneys.
Fosinopril is available in both brand-name version and generic-name version. It is sold under the common brand name “Monopril.” The generic drugs usually cost less than the brand name version.
What is Fosinopril used for?
Fosinopril is used to treat hypertension. Lowering high blood pressure prevents heart attacks, strokes and kidney problems. In addition to taking medicine, lifestyle changes will also help to control your blood pressure.
It is used in the treatment of congestive heart failure in combination with diuretics and digitalis.
Left ventricular dysfunction after myocardial infarction:
It is used to improve the chances of survival after myocardial infarction in a clinically stable individual with left ventricular dysfunction manifested as an ejection fraction less than or equal to 40% and to decrease the rate of overt heart failure and subsequent hospitalizations for congestive heart failure in these patients.
How to use Fosinopril?
Take Fosinopril exactly as instructed usually once or twice daily. Do not alter your dosage or take it more frequently than prescribed by your doctor.
Take this drug orally with or without food or as instructed by your doctor. The dose of the drug is based on your medical condition and response to treatment.
Antacids that include aluminum or magnesium can reduce the absorption of fosinopril. If you are taking an antacid, take it at least 2 hours before or after taking this product.
If you are using tablet form swallow the whole tablet; do not split, chew, or crush them.
It controls hypertension but does not cure it. Do not discontinue using Fosinopril without consulting your doctor even if you feel better. Many people with hypertension do not feel sick.
To lower the risk of side effects, your doctor may advise you to start this medication at a low dose initially and gradually increase your dose. Follow your doctor’s guidance carefully.
Hypertension (high blood pressure) treatment may require several weeks before you observe the full benefit of this medication. Inform your doctor, if your condition remains the same or if it gets worse (such as your blood pressure readings remain constant or increase).
What are the side effects of Fosinopril?
The commonly observed side effects with the use of this drug include dizziness, skin rash, loss of taste and a persistent dry cough. Inform your doctor immediately If any of these side effects continue or worsen.
To minimize the risk of dizziness and lightheadedness get up slowly when rising from a sitting position or lying position.
Get medical assistance right away if you observe any severe side effects like fainting, symptoms of high potassium (like muscle weakness and slow or irregular heartbeat) signs of infection (such as fever, chills, persistent sore throat) and cloudy urine.
Although this drug is used to prevent kidney problems or treat people who have kidney problems, it may also rarely produce severe kidney problems or make them dangerous. Your doctor will test your kidney function while you are taking Fosinopril. Notify your doctor quickly if you experience any symptoms of kidney problems like a change in the amount of urine.
Fosinopril may cause serious (possibly fatal) liver problems. Get medical assistance as soon as possible if you have any symptoms of the liver problem, like non-stop nausea/vomiting, dark urine, loss of appetite, stomach/abdominal pain or yellowing eyes/skin.
A severe allergic reaction to this drug is uncommon. However, get medical help quickly if you mark any symptoms of a severe allergic reaction such as rash, itching/swelling (particularly of the face/tongue/throat), trouble breathing or severe dizziness.
This record does not contain the full list of all possible side effects. If you mark other effects not listed above, contact your doctor/pharmacist.
What are the precautions while using Fosinopril?
Inform your doctor/pharmacist before taking Fosinopril, if you are allergic to it; or if you have other allergies. This drug may also contain some inactive ingredients that can cause allergic reactions or other problems. Talk to your doctor/pharmacist for more information.
Inform your doctor/pharmacist about all the products you are using including prescription, non-prescription, vitamins, nutritional supplements, and herbal products.
Notify your doctor right away if you see any sign of infection (like a sore throat, fever), as it may be a sign of neutropenia (low level of neutrophils) or of progressive edema which might be related nephrotic syndrome.
Fosinopril may cause dizziness, do not drive, use machinery, or do anything that needs sharpness until you can do it cautiously. Limit use of alcoholic beverages. Speak to your doctor if you are using marijuana.
Too much sweating, diarrhea or vomiting may lead to severe dehydration and fall in blood pressure because of reduction in fluid volume. Inform your doctor if you have prolonged diarrhea or vomiting. Make sure to take enough fluids to prevent dehydration unless your doctor directs you otherwise.
This product may increase potassium levels in your body, before using potassium supplements or salt substitutes that consist of potassium, seek advice from your doctor.
Older adults are susceptible to the side effects of this drug, mainly dizziness and increase in potassium level.
Some people on Fosinopril therapy for heart failure should be warned against rapid increases in physical activity.
This medication is not advised for use during pregnancy. It may harm an unborn baby. Ask your doctor for further details (See also Warning).
This medication passes into breast milk. Ask your doctor before breastfeeding.
What are the drug Interactions of Fosinopril?
Fosinopril may interact with other medications, herbs, or vitamins you may be using. A drug interaction is when a substance changes the way a drug works which can be harmful or block the drug from working well.
Do not start, stop, or alter the dose of the drug without consulting your doctor because your doctor may be monitoring you for all possible drug interactions.
Double blockade of the renin-angiotensin system with angiotensin receptor blockers, ACE inhibitors, or aliskiren may develop hyperkalemia, hypotension, and changes in renal function (acute renal failure) compared to monotherapy. Regularly monitor blood pressure, renal function and electrolytes in people using Fosinopril and other drugs that affect the RAS.
A serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) along with fosinopril. Make sure to inform your doctors about which medicines you are using.
Taking potassium-sparing diuretics like spironolactone, amiloride, triamterene along with Fosinopril may lead to high blood potassium in your body.
Fosinopril interacts with some medicines like everolimus, sirolimus that decrease the immune system/increase the risk of infection.
Some products may contain ingredients that could raise your blood pressure or increase the risk of heart failure. Tell your doctor/pharmacist what products you are using, and ask how to use them safely (particularly cough-and-cold products, NSAIDs such as ibuprofen/naproxen, diet aids).
A reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) along with Fosinopril. Make sure all your doctors know about the medicines you are using.
Do not take this drug during pregnancy because Fosinopril can harm the unborn baby or end your pregnancy. Discuss with your doctor about other ways to lower your blood pressure if you plan to get pregnant. If you get pregnant while taking Fosinopril, tell your doctor right away.
This drug can cause severe, sudden swelling of your face, arms, legs, lips, tongue, throat, and intestines. This swelling can be fatal. Stop this medicine right away and inform your doctor right away if you have swelling or have stomach pain.
Low blood pressure warning:
This drug can cause low blood pressure, mainly at the start of treatment. Tell your doctor if you feel lightheaded or faint.
This drug may decrease white blood cell counts. This can increase your risk of infections. Inform your doctor promptly if you notice any signs of infection, like a fever or a sore throat.
What are the forms and strengths of Fosinopril?
Form: Oral tablet
Strengths: 10mg, 20mg and 40mg
Form: Oral tablet
Strengths: 10mg, 20mg and 40mg
What is the dosage of Fosinopril?
10 mg orally once a day initially, no more than 40 mg/day.
Dosage is based on the weight in children below 18 years.
Children (below 50 kg): Limited data suggest 0.1-0.6 mg/kg orally once a day.
Children (50 kg and above): As adults; 5-10 mg orally once a day initially, not to exceed more than 40 mg/day.
For Congestive Heart Failure:
Adjunctive to diuretics with digitalis
5-10 mg orally once a day initially, no more than 40 mg/day
Beneficial for many patients at risk for heart disease; reduce the risk of MI, stroke, diabetic nephropathy, microalbuminuria, new onset diabetes mellitus.
Consider starting an ACE inhibitor in high-risk patients, even if no hypertension or Congestive Heart Failure (CHF).
May prolong survival in CHF, may preserve renal function in diabetes mellitus.
May help to prevent migraine headache.
No sexual dysfunction side effect.
Good choice in hyperlipidemic patients.
Requires weeks for full effect; to start, use low dose and titrate every 1-2 weeks.
Abrupt discontinuance not associated with rapid increase in BP.
Most common questions asked about Fosinopril / Q&A’s:
What are the serious side effects of Fosinopril?
Some of the serious side effects of Fosinopril may include swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs, hoarseness, difficulty in breathing or swallowing, yellow discoloration of the skin or eyes, fever, sore throat, chills, and other signs of infection, lightheadedness, fainting. Seek a medical emergency as soon as possible if you notice any of these side effects.
What are the symptoms of Fosinopril overdose?
Symptoms of Fosinopril overdose include lightheadedness, dizziness, and fainting. Seek medical emergency as soon as possible if you notice any of these side effects.