GENERIC NAME: Celecoxib

COMMON BRAND: Celebrex

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It acts by decreasing the amount of prostaglandins (cyclooxygenase COX-1 and COX-2) produced in your body. It is used to treat acute pain, rheumatoid arthritis, osteoarthritis, dysmenorrhea (painful menstruation) and menstrual symptoms, and is also used to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

Celecoxib is available in both brand-name version and generic-name version. It is sold under the common brand names “Celebrex. The generic drugs usually cost less than the brand name version.

The research conducted on celecoxib shows the potential cancer chemopreventive activity (agents used to inhibit, delay, or reverse carcinogenesis) and therapeutic drugs in clinical trials for a variety of malignancies.

What is Celecoxib used for?

Analgesia: This drug is used to treat mild to moderate pain of headaches, muscle aches and dental pain.

Primary dysmenorrhea: This drug is also used to relieve mild to moderate menstrual pain or cramps.

Primary dysmenorrhea is a pain in the lower abdomen that usually occurs before or during menstruation, in the absence of other diseases such as endometriosis.

This drug is used to reduces pain, swelling, and joint stiffness caused by the following conditions:

Rheumatoid arthritis: It is a condition that causes pain, swelling, and stiffness of the joint.

Osteoarthritis: It is a common chronic joint condition that causes pain, stiffness, and other symptoms.

Ankylosing spondylitis: It is a type of arthritis that primarily affects the spine. It causes severe inflammation of the vertebrae that might lead to chronic pain and disability.

Tendinitis: It is a painful condition in which tendon sheath get inflamed.

Bursitis: It is a painful condition that affects the small, fluid-filled sacs called bursae that cushion the bones, tendons and muscles near joints.

Acute gout: It is a common and complex form of arthritis that is characterised by sudden, severe attacks of pain, swelling, redness and tenderness in the joints.

Familial adenomatous polyposis: This drug is also used to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

Familial adenomatous polyposis is a condition characterised by the presence of numerous internal polyps which affects the colon and in which the polyps may become malignant.

How to use Celecoxib?

Read the medication guide carefully given by your pharmacist before you start taking celecoxib and whenever you get a refill. If you have any problem or you do not understand any part, discuss with your doctor or pharmacist.

Take this medication orally, usually 1-2 times in a day with a full glass of water or as advised by your doctor. Do not lie down wait for at least 10 minutes after taking this drug. To avoid gastrointestinal problems (like stomach upset) take this drug with food, milk or antacid.

Celecoxib may cause stomach or intestinal bleeding, which can be fatal. Older adults are more sensitive to these side effects. To reduce the risk of GIT bleeding and other side effects, take this medication at a lower dose and only for the prescribed length of time. For conditions like arthritis, continue to take this medication up to two weeks until you get the full benefit.

Do not change your dose or take it more frequently than directed by your doctor. Pain medication works best if they are used with the first signs of pain. If you wait until your pain worsens, the medicine may not work well.

Inform your doctor if your pain remains or get worst or if you develop any new symptoms.

What are the side effects of Celecoxib?

The common side effects observed with the use of this drug are nausea, vomiting, stomach upset, heartburn, headache, bloating, gas, constipation, diarrhoea, dizziness and respiratory tract infection. If any of these effects remain or get worse, notify your doctor immediately.

Get emergency medical assistance if you notice symptoms of GIT bleeding or ulcers such as stomach pain or abdominal pain, black/sticky stools and bloody vomit.

This drug rarely causes severe, possibly fatal liver damage and can even lead to liver failure. The symptoms of liver damage are persistent nausea/vomiting, weakness, severe stomach/abdominal pain, dark urine, yellowing eyes/skin. If you notice any of the theses side effects, stop taking celecoxib and consult your doctor or pharmacist right away.

Get emergency help right away if you notice any of the following symptoms like breathlessness, weakness in one side of your body, chest pain, swelling of the face or throat and slurred speech.

Seek medical assistance promptly, if you notice any severe side effects, like easy bruising/bleeding, pain/swelling/warmth in the groin/calf, signs of kidney problems (like a change in the amount of urine), symptoms of heart failure (like swelling ankles/feet, unusual tiredness).

This drug may increase your blood pressure. Monitor your blood pressure regularly and tell your doctor if the results are high.

Inform your doctor instantly if you notice any signs or symptoms of unexplained weight gain or edema.

This document does not include all possible side effects. If you see other side effects not listed above, reach out to your doctor or pharmacist.

What are the precautions while using Celecoxib?

Inform your doctor/pharmacist before taking celecoxib, if you are allergic to it; or if you have other allergies (including aspirin and other NSAIDs like ibuprofen etc.). This drug may also contain some inactive ingredients that can cause allergic reactions or other problems. Talk to your doctor/pharmacist for more information.

Inform your doctor/pharmacist about all the products you are using including prescription, non-prescription, vitamins, nutritional supplements, and herbal products.

Before taking celecoxib, discuss with your doctor or pharmacist about your medical history especially of aspirin-sensitive asthma, severe kidney disease, recent heart bypass surgery (CABG), active bleeding/sores in stomach/intestines (ulcer, gastrointestinal bleeding), blood disorders (like anemia), high blood pressure, diabetes, liver disease, nasal polyps, obesity, tobacco use, stroke, swelling of the ankles/feet/hands.

Celecoxib may cause stomach or intestinal bleeding, which can be fatal, older adults are more susceptible to this condition. Regular use of this drug with alcohol and tobacco may increase your chances for stomach bleeding. Restrict the use of alcohol and stop smoking. Consult your doctor/pharmacist for further information.

NSAIDs like celecoxib sometimes can cause kidney problem which is more likely to occur if you have kidney disease or have heart failure, in severe dehydration, or an older adult. To avoid kidney problems take plenty of water. Notify your doctor instantly if you have a change in the amount of urine.

Caution is recommended when using celecoxib for children with a particular type of arthritis like systemic onset juvenile rheumatoid arthritis as they may be at high risk for a severe bleeding/clotting problem (disseminated intravascular coagulation). Get medical assistance right away if children develop sudden bleeding/bruising or bluish skin in the fingers/toes.

Older adults are susceptible to the side effects of this drug especially to stomach bleeding and kidney problems. Therefore, caution is required while using this drug in older adults.

During pregnancy, use this medication only when benefits outweigh the risk and only if prescribed by your doctor. It is not advised to use this drug during the first and last trimesters of pregnancy as it may harm to the fetus and interference with normal delivery/labour.

This drug may pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

What are the drug interactions of Celecoxib?

Celecoxib may interact with other medications, herbs, or vitamins you may be using. A drug interaction is when a substance changes the way a drug works which can be harmful or block the drug from working well.

Do not start, stop, or alter the dose of the drug without consulting your doctor because your doctor may be monitoring you for all possible drug interactions.

Some products that may interact with celecoxib are aliskiren, ACE inhibitors (like captopril, lisinopril), angiotensin II receptor blockers (like losartan, valsartan), cidofovir, corticosteroids (like prednisone), or diuretics (like furosemide), ketorolac.

Celecoxib may increase the levels of certain mental health drug like lithium in your body. Symptoms of lithium toxicity include slurred speech and tremors.

Taking “blood thinners” such as dabigatran/enoxaparin/warfarin and anti-platelet drugs such as clopidogrel with celecoxib increases the risk of severe stomach bleeding.

Take advice from your doctor/pharmacist before using any over-the-counter medicine for cold, allergy, or pain. Many over-the-counter medications contain aspirin or other NSAIDs similar to celecoxib (such as mefenamic acid, naproxen, etc.). Taking these products together with celecoxib can increase the concentration of celecoxib in your body which may result in severe side effects. Read the medication label carefully to check if the medicine contains aspirin or any other NSAIDs. However, you should continue using aspirin if you are already using it for the prevention of heart attack or stroke but only on doctor’s advice.

Celecoxib like some other NSAIDs may interfere with specific laboratory tests, giving a false test result. Make sure that laboratory personnel and all your doctors know you use this drug.

WARNINGS:

Heart risk:

Celecoxib may increase the risk of heart problems, such as blood clot, heart attack, stroke, or heart failure which can be fatal. The risk may increase if you already have heart disease or have taken celecoxib for an extended period or at high doses.

Coronary artery bypass graft warning:

This drug is contraindicated for the treatment of pain before coronary artery bypass graft (CABG) surgery (heart surgery is done to increase blood flow to the heart). Taking this drug before surgery will increase the risk of heart attack and stroke.

Gastrointestinal:

This drug may increase your risk of stomach problems, like bleeding, or peptic ulcers which can be fatal. These conditions can occur at any time and without any warning signs. If you are above 65 years, you may have a greater chance for severe stomach issues.

What are the forms and strengths of Celecoxib?

Generic: Celecoxib
Form: Oral capsule
Strengths: 50mg, 100mg, 200mg, and 400mg

Brand: Celebrex
Form: Oral capsule
Strengths: 50mg, 100mg, 200mg, and 400mg

What is the dosage of Celecoxib?

For Mild to Moderate Pain:

Adult (18 years and above):

Typical dose: Take 400mg for the initial dose, followed by a 200mg dose after about 8–12 hours if needed. On following days, the usual dose of 200mg taken twice per day as needed.

Children (0–17 years):

Avoid use of this drug in children below 18 years of age, as the studies have not been established.

For Osteoarthritis:

Adult (18 years and above):

Typical dose: Take 200mg once per day, or take 100mg twice per day in morning or evening after food.

Children (0–17 years):

Avoid use of this drug in children below 18 years of age, as the studies have not been established.

For Rheumatoid Arthritis:

Adult (18 years and above):

Typical dose: Take 100–200 mg taken twice per day in morning or evening after food.

For Juvenile Rheumatoid Arthritis:

Children (2 to 17 years):

For children who weigh is 22–55 pounds (10–25kg), the typical dosage is 50mg taken twice per day in morning and evening after food.
For children who weigh above 55 pounds (25kg), the typical dosage is 100mg taken twice per day in morning and evening after food.

Children ( 0 to 1 year):

Avoid use of this drug in children below 2 years of age, as the studies have not been established.

For Ankylosing Spondylitis:

Adult (18 years and above):

Typical dose: Take 200mg once per day or 100mg taken twice per day in morning and evening after food. If required your doctor may double the dose to 400mg per day (single or divided doses).

Children (0–17 years):

Avoid use of this drug in children below 18 years of age, as the studies have not been established.

For Menstrual Pain:

Adult (18 years and above):

Typical dose: Take 400mg for the initial dose, followed by a 200mg dose after about 8–12 hours if needed. On following days, the typical dose of 200mg taken twice per day as needed.

Children (0–17 years):

Avoid use of this drug in children below 18 years of age, as the studies have not been established.

Special Considerations:

Liver impairment: People with liver disease may have reduced the ability to clear this drug from the body, which results in more side effects. If you have mild to moderate liver disease, your daily dose of celecoxib may be reduced by half. If you have severe liver disease, avoid taking this medication.

Most common questions asked about Celecoxib / Q&A’s:

What are the symptoms of Celecoxib overdose?

Celecoxib overdose symptoms may include lack of energy, drowsiness, nausea, vomiting, stomach pain, vomiting material that is bloody or looks like coffee grounds, bloody or black, tarry stools, loss of consciousness, hives, rash, swelling of the face, eyes, tongue, lips, throat, arms, hands, feet, ankles, or lower legs, difficulty breathing or swallowing. Seek a medical emergency as soon as possible if you experience any of these symptoms.

Disclaimer

TheMedPharma has made every effort to make sure that all the information is factually correct, comprehensive, and up-to-date. However, this website should not be considered as a substitute for the advice, knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or licensed health care professional before taking any medication. The drug information contained herein is subjected to changes if required. The lack of warnings or other information for a given drug does not mean that the drug or its combination is safe, effective or appropriate for use in all patients.