GENERIC NAME: Candesartan

COMMON BRAND: Atacand

Candesartan is an oral antihypertensive prescription drug, belongs to a class of medications known as angiotensin receptor blockers (ARBs). Candesartan works by blocking the action of angiotensin II (a natural substance) and thereby relaxing blood vessels to flow blood smoothly and helps the heart to pump more efficiently.

It is available as the brand-name drug and generic drug. It is sold under the common brand “Atacand”. Generic drugs usually cost less.

What is Candesartan Cilexetil used for?

Hypertension:

Candesartan is either used alone or in combination with other drugs to reduce high blood pressure. It also reduces the risk of stroke in people who have high blood pressure.

Heart Failure:

Candesartan is used to treat heart failure in people with left ventricular systolic dysfunction (ejection fraction less than 40 %) to reduce cardiovascular death and to reduce heart failure hospitalizations.

How to use Candesartan Cilexetil?

The dose of the drug is based on your medical condition and response to treatment. Take this drug orally as directed by your doctor, usually once per or twice a day with or without food.

Candesartan comes with the medication guide read all the instruction carefully before you start taking it. If you have any problem, discuss with your doctor or pharmacist.

Take candesartan regularly even if you feel well to get the full benefit from it. Preferably take this drug at the same time each day to avoid confusion.

Take the whole tablet with a full glass of water or other liquids. Do not crush, break, or chew it.

Discuss with your doctor if your condition remains or if it gets worse (your blood pressure readings increase).

To reduce the risk of side effects, the doctor may advise you to start this medication at a low dose initially and gradually increase your dose. Follow your doctor’s guidance carefully.

What are the side effects of Candesartan Cilexetil?

The commonly observed side effect with this drug is dizziness or lightheadedness, flu-like symptoms such as fever, sneezing, cough, and a runny nose, sore throat, nasal congestion. If any of these effects remain or get worse, talk to your doctor or pharmacist immediately.

To lessen the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Get emergency medical assistance promptly, if symptoms of hyperkalemia (high potassium blood level) occur such as a slow/irregular heartbeat, muscle weakness and feeling ill.

This drug very rarely causes serious kidney problems or make them worse. Inform your doctor on time, if you notice any signs of kidney problems like a change in the amount of urine tiredness and shortness of breath.

Get emergency medical assistance right away if you notice any sign or symptoms of low blood pressure such as feeling faint or dizzy, lightheadedness and tiredness.

Allergic reaction to this medicine is very rare. However, get medical help promptly if you notice any symptoms of a severe allergic reaction, such as rash, itching/swelling (face/tongue/throat), breathlessness.

This is not a full record of all possible side effects. If you mark other effects not listed above, contact your doctor or pharmacist.

What are the precautions while using Candesartan Cilexetil?

Before using candesartan, notify your doctor or pharmacist if you are allergic to it or if you have any other allergies.

Inform your doctor or pharmacist about medical history, mainly of liver disease, kidney problems, dehydration (severe loss of body water and minerals), hyperkalemia (high blood levels of potassium in the blood).

Candesartan may increase your blood potassium levels. Ask your doctor before you using any medicines, supplements, or salt substitutes that contain potassium.

Do not take alcoholic beverages until you have discussed with your doctor as alcohol may make the low blood pressure effect worse or increase the possibility of dizziness or fainting.

Do not take other medicines without consulting your doctor, primarily such as prescription or nonprescription (over-the-counter) medicines for asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

The use of this medicine is not recommended during pregnancy as it may harm the fetus. Consult your doctor for further details.

It is not clear whether this drug can passes into breast milk. Consult your doctor before breastfeeding.

What are the drug interactions of Candesartan Cilexetil?

Candesartan may interact with other medications, vitamins, or herbs you may be using. A drug interaction is when a substance changes the way a drug works which can be harmful or hinder the drug from working well.

Do not start, stop, or alter the dose of the drug without consulting your doctor as your doctor may be monitoring you for possible drug interactions.

Taking angiotensin receptor blockers (losartan, valsartan, telmisartan) and angiotensin-converting enzyme inhibitors (enalapril, lisinopril, captopril) with this drug may raise your risk of very low blood pressure, high blood potassium levels, and worsened kidney function.

Some products may interact with candesartan such as lithium, aliskiren and birth control pills containing drospirenone.

Some medications contain inactive ingredients that could raise your blood pressure or worsen your heart failure. Tell your doctor what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs like ibuprofen/naproxen).

This drug may cause low blood pressure, and the risk of low blood pressure is higher if you also take diuretics (water pills). Examples of diuretics include hydrochlorothiazide, furosemide, spironolactone.

WARNINGS:

High blood potassium warning:

This drug may increase your blood levels of potassium. Your doctor will check your blood potassium levels during treatment with this drug.

Risk of hypotension warning:

This drug may cause hypotension (low blood pressure). Your doctor will observe you for low blood pressure at the time of dosage changes. Inform your doctor if you have any symptoms of low blood pressure, such as dizziness or lightheadedness.

Kidney damage warnings:

Candesartan may cause severe kidney damage especially in people with certain types of kidney damage or heart failure. Your doctor will regularly monitor your kidney function while you are taking this drug.

Pregnancy:

This drug must not be taken in pregnancy or if you are planning to get pregnant. Olmesartan can harm the fetus or end your pregnancy. Inform your doctor right away if you are pregnant while using this drug.

What are the forms and strengths of Candesartan Cilexetil?

Generic: Candesartan
Form: Oral tablet
Strengths: 4mg, 8mg, 16mg, 32mg

Brand: Atacand
Form: Oral tablet
Strengths: 4mg, 8mg, 16mg, 32mg

What is the dosage of Candesartan Cilexetil?

For High Blood Pressure (hypertension):

Adult dosage (18–64 years):

Standard dose: Take 16mg by mouth once daily if this drug is taken alone.
The total daily dose can range from 8–32mg in 1 or 2 divided doses.

Children (6 to 17 years):

For children less than 50kg:

Initial dose: Take 4–8mg per day. Doses can range from 2–16mg/day.

For children more than 50kg: 

Initial dose: Take 8–16mg per day. Doses can range from 4–32mg per day.

The dose may be taken by orally once per day or twice a day in two equal doses.
For children who cannot swallow tablets, consider using an oral suspension.

Children (1 to 5 years):

Typical dose: Range from 0.05–0.4mg/kg of body weight per day. The standard initial dose: 0.20mg/kg per day.

The dose may be taken orally once per day, or twice a day in two equal doses.

For children who cannot swallow tablets, consider using an oral suspension.

Children (below 1 year):

This drug has not been studied in this age group.

Senior dosage (65 years and older):

In older adults, the dose of the drug needs to be reduced, or given at a different schedule because older adults eliminate drugs more slowly. This causes the accumulation of medicine in the body. Your doctor may prescribe a lower dose if you are an older person.

Special Dosage Considerations:

Adults:

Moderate liver problems: 8mg per day.
Severe kidney problems: A starting dose of 8mg or less per day.

Children (1 to 17 years):

With kidney problems: Children with poor renal function (GFR less than 30 ml/min/ 1.73 m2) shouldn’t take this drug.

For Heart Failure:

Adult (18 to 64 years):

4mg orally once a day. Your doctor may increase your dosage gradually up to a maximum of 32mg per day.

Children (0 to 17 years):

The use of this drug is not adviced in children below 18 years of age as safety and efficacy have not been established.

Senior dosage (65 years and older):

In older adults, the dose of the drug needs to be reduced, or given at a different schedule because older adults eliminate drugs more slowly. This causes the accumulation of medicine in the body. Your doctor may prescribe a lower dose if you are an older person.

Most common questions asked about Candesartan / Q&A’s:

What are the symptoms of Candesartan overdose?

Candesartan overdose symptoms may include dizziness, fainting, fast or slow heartbeat. Seek a medical emergency as soon as possible if you experience any of these symptoms.

Disclaimer

TheMedPharma has made every effort to make sure that all the information is factually correct, comprehensive, and up-to-date. However, this website should not be considered as a substitute for the advice, knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or licensed health care professional before taking any medication. The drug information contained herein is subjected to changes if required. The lack of warnings or other information for a given drug does not mean that the drug or its combination is safe, effective or appropriate for use in all patients.