GENERIC NAME: Acebutolol

COMMON BRAND: Sectral

Acebutolol is an oral prescription drug belongs to a class of medications called cardioselective beta-adrenoreceptor blockers. It has mild intrinsic sympathomimetic activity used for treating people with hypertension and ventricular arrhythmias.

Acebutolol work by preventing adrenaline (norepinephrine) from acting on beta-adrenoreceptors that are present in blood vessels and the heart. This causes blood vessels to relax and slow down the heart rate to improve blood flow, decrease blood pressure and reduce strain on the heart.

What is Acebutolol used for?

Hypertension:

This drug is used to treat hypertension in adults either alone or in combination with other antihypertensive medications (such as thiazide diuretics). Lowering blood pressure helps to prevent strokes, heart attacks, and kidney problems.

Ventricular Arrhythmias:

It is also used in the treatment of ventricular arrhythmias (irregular heartbeat). Treating arrhythmias reduces heart workload and decrease the demand for oxygen. Irregular heartbeats can be severe and sometimes lead to a heart attack.

How to use Acebutolol?

Take acebutolol capsule orally with food or without food, as directed by the doctor, usually 1-2 times in a day. The dosage of this drug depends on your medical condition and response to the treatment.

To help you remember to take this drug at the same time each day. Carefully follow all the directions on your prescription label, and ask your doctor or pharmacist to explain any part you do not understand. Take acebutolol exactly as directed. Do not alter your dose or take it more frequently than prescribed by your doctor.

Use this medication regularly as instructed by your doctor to get the most benefit from it. It is crucial to continue this drug even if you feel better. Most of the people having hypertension (high blood pressure) do not feel sick. If you abruptly discontinue taking acebutolol, you may experience serious heart problems like angina (chest pain) or heart attack.

You may have to wait for 1 to 2 weeks to observe the full benefit of this medicine. Inform your doctor if your medical condition remains unchanged or if it worsens (for example, if your blood pressure remains high or chest pain occurs more often).

What are the side effects of Acebutolol?

The common side effects observed with the use of this drug include dizziness, lightheadedness, excessive tiredness, headache, constipation, ddiarrhea stomach upset and muscle aches. If any of these effects remain or worsen, inform your doctor/pharmacist immediately.

Get up slowly from a sitting/lying position, as this may help to lessen the risk of dizziness and lightheadedness.

Acebutolol may reduce blood flow to your hands and feet, causing them to feel cold. Avoid smoking or chewing of tobacco as this may worsen this effect.

Get emergency medical assistance right away if you notice any severe side effects, such as low blood pressure (severe dizziness, lightheadedness, fainting), slow heart rate (tiredness, severe dizziness, lightheadedness, fainting), symptoms of asthma (feelings of tightness in the chest, breathlessness, cough, wheezing), poor circulation (cold or blue fingers or toes), signs of heart failure (breathlessness, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain), mental/mood changes (depression, confusion, memory problems), vision changes, liver disease (dark urine, persistent nausea, vomiting, stomach/abdominal pain, yellowing eyes/skin).

A severe allergic reaction to this drug is very rare. However, a severe allergic reaction that includes rashes, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing may occur. Get emergency medical assistance immediately if you notice any of the above side effects.

This is not a complete record of all possible side effects. Inform your doctor at the earliest, if you notice any of the side effects that are not mentioned in this article.

See also Warning and Precautions sections.

What are the precautions while using Acebutolol?

Inform your doctor/pharmacist before taking acebutolol, if you are allergic to it; or to any other beta-blockers (for example atenolol, metoprolol, propranolol); or if you have other allergies. Acebutolol capsule may also contain some inactive ingredients that can cause allergic reactions or other problems. Talk to your doctor/pharmacist for further information.

Inform your doctor/pharmacist about all the products you are using including prescription, non-prescription, vitamins, nutritional supplements, and herbal products.

Before taking acebutolol, tell your doctor/pharmacist about your medical history, mainly of blood circulation problems (like Raynaud’s disease, peripheral vascular disease), heart problems (like heart failure, heart attack, heart rhythm problems), kidney problems, liver problems, breathing problems (like asthma, chronic bronchitis, emphysema), mental/mood disorders (like depression), a specific muscle disease (myasthenia gravis), hyperthyroidism and severe allergic reactions.

If you have diabetes, acebutolol may mask the symptoms of hypoglycemia (sudden fall in blood sugar level) such as fast/pounding heartbeat you would usually feel when you are hypoglycemic. Other symptoms of hypoglycemia such as sweating and dizziness, does not change by this drug. This drug can also make it difficult to control your blood sugar level. Monitor your blood sugar levels regularly share the results with the doctor. Inform your doctor immediately if you have any symptoms of hyperglycemia (high blood sugar level) such as an increase in thirst or urination. Your doctor may recommend you exercises, diet or may adjust your diabetes medication.

This drug may cause you dizzy. Alcohol or marijuana can make you dizzier. Avoid driving, use of machinery or doing anything that needs sharpness until you can do it safely. Limit alcoholic beverages. Speak to your doctor/physician if you are using marijuana.

During pregnancy, acebutolol should be used only when benefits outweigh the risk. It may be harmful to the foetus. This drug can also cross into breast milk and for more information about the safety of drug talk to your doctor.

What are the drug interactions of Acebutolol?

Acebutolol may interact with other medications, herbs, or vitamins you may be using. A drug interaction is when a substance changes the way a drug works which can be harmful or hinder the drug from working well.

Do not start, stop, or alter the dose of the drug without discussing your doctor because your doctor may be monitoring you for possible drug interactions.

NSAIDs (such as diclofenac, ibuprofen, indomethacin, ketorolac, nabumetone, naproxen), a nasal decongestant (such as phenylephrine, pseudoephedrine), cough-and-cold products, may decrease the effectiveness of acebutolol. Products that may interact with acebutolol are dolasetron, fingolimod.

WARNINGS:

Stopping the drug:

Do not suddenly stop this medication without informing your doctor. Some conditions may become dangerous when you suddenly discontinue this drug. In some people who have abruptly terminated taking similar drugs have had chest pain, heart attack, and even irregular heartbeat. If your doctor recommends you to stop this drug, your doctor may ask you to reduce your dose gradually.

When you gradually decrease the dose of this drug before discontinuing this medication, your doctor may recommend you to restrict physical activity to reduce pressure on your heart. Get medical emergency assistance immediately if you notice symptoms such as chest pain/tightness/pressure, unusual sweating, trouble in breathing, chest pain spreading to the jaw/neck/arm, or fast/irregular heartbeat.

Other conditions:

Before taking acebutolol, inform your doctor about all of your health conditions such as diabetes, chronic obstructive pulmonary disease (COPD), asthma, poor circulation, heart failure or other heart problems, hyperthyroidism.

What are the forms and strengths of Acebutolol?

Generic: Acebutolol
Form: Oral capsule
Strengths: 200mg, 400mg

Brand: Sectral
Form: Oral capsule
Strengths: 200mg, 400mg

What is the dosage of Acebutolol?

For Hypertension (high blood pressure):

Adult (18–64 years):

Initial dose: Take 400mg once per day, or take 200mg twice per day.
Dosage increases: Your doctor may increase your dosage up to 600mg taken twice per day as needed.
Maintenance dose: range from 400–800mg per day.

Children (0 to 17 years):

Avoid use of this drug in children below 18 years of age, as the studies have not been established yet.

Geriatric (65 years and older):

There is no fixed dose. In an older adult, your body may process this drug slowly. Your doctor may start the treatment at a lower dosage to prevent drug build up the body. Your total daily dose shouldn’t be more than 800 mg.

For Arrhythmia (irregular heartbeat):

Adult (18 to 64 years):

Initial dose: Take 200mg twice per day.
Dosage increases: Your doctor slowly increases your dose up to 600mg taken twice per day.
Maintenance doses: Range from 600–1200mg per day.

Children (0 to 17 years):

Avoid use of this drug in children below 18 years of age, as the studies have not been established yet.

Geriatric (65 years and older):

There is no fixed dose. In an older adult, your body may process this drug slowly. Your doctor may start the treatment at a lower dosage to prevent drug build up the body. Your total daily dose shouldn’t be more than 800 mg.

Special Dosage Considerations:

For people with kidney problems: If you develop moderate kidney problems (CrCl < 50 mL/min), your doctor will reduce your dosage by 50 per cent. If you develop severe kidney problems (CrCl < 25 mL/min), your doctor will lower your dosage by 75 %.

Most common questions asked about Acebutolol / Q&A’s:

Can you drink coffee while taking beta blockers such as Acebutolol?

You should avoid caffeine or caffeine-containing products or taking any over-the-counter medicines for cough and cold, antihistamines, aluminium-containing antacids. You must also avoid alcohol because it can reduce the efficacy of beta-blockers.

Disclaimer

TheMedPharma has made every effort to make sure that all the information is factually correct, comprehensive, and up-to-date. However, this website should not be considered as a substitute for the advice, knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or licensed health care professional before taking any medication. The drug information contained herein is subjected to changes if required. The lack of warnings or other information for a given drug does not mean that the drug or its combination is safe, effective or appropriate for use in all patients.